ajrcmb.atsjournals.orgAmerican Journal of Respiratory Cell and Molecular Biology

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Abstracts AJRCMB AJRCMB Home Current Issue Articles in Press Archive AnnalsATS AnnalsATS Home Current Issue Articles in Press Archive ATS Scholar More Conference Abstracts CME Content About CME Your Exam Activity Browse Exams Search in: Anywhere Citation This Journal Advanced Search Publishes the most significant and original observations in the area of respiratory and lung cell biology, including cellular, biochemical, molecular, developmental, genetic, and immunologic studies in health and in acute and chronic disorders related to the respiratory system and sleep Current Issue Articles in Press Archive Current Issue Highlights Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation Macrophage effector function is dynamic in nature. These findings demonstrate that glycolysis is dispensable for macrophage effector function in tissue-resident alveolar macrophages and highlight the importance of macrophage tissue origin (tissue resident vs. recruited) in immunometabolism. FEBRUARY 2020 AJRCMB Rats with a Human Mutation of NFU1 Develop Pulmonary Hypertension This study describes the first humanized genetic rat model to spontaneously develop pulmonary arterial hypertension (PAH). Rats with deficient NFU1 produced a strong PAH phenotype with proliferative changes in the lung vasculature and right-heart hypertrophy. The authors also provide a molecular characterization of the model. FEBRUARY 2020 AJRCMB Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier These data demonstrate that downregulation of Piezo1 signaling in endothelium is a critical factor in the pathogenesis of ventilator-induced lung injury, and thus augmenting Piezo1 expression or pharmacologically activating Piezo1 signaling may be an effective therapeutic strategy. FEBRUARY 2020 AJRCMB Activation of the Metabolic Master Regulator PPARγ: A Potential PIOneering Therapy for Pulmonary Arterial Hypertension The authors discuss preclinical basic translational findings and randomized controlled trials related to PPARγ agonists of the thiazolidinedione class, with a particular focus on the last 5 years. The convincing recent clinical trial data on the lack of significant toxicity in high-risk populations justify the timely conduct of clinical studies to achieve “repurposing” or “repositioning” of pioglitazone for the treatment of clinical PAH. FEBRUARY 2020 AJRCMB About the Journal Subscribe Submit an Article About the Journal Editorial Board Instructions for Contributors Meet the Editors Reprints and E-Prints Latest Issue Table of Contents About the Cover Cover Gallery Journal Metrics Impact Factor The Journal Impact Factor is... -- 4.34 Google h5-index h5-index is the h-index for articles published in the last 5 complete years. It is the largest number h such that h articles published in 2011-2015 have at least h citations each. -- 47 Full-Text Views These are the full-text views from the year 2016. -- 1 Million Acceptance Rate The Journal acceptance rate is... -- 30% Time to First Decision Average time before authors recieved notice on first decision -- 14 days More Metrics Social AJRCMB Twitter Most Read The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease Schiller et al. Published Online: Jul 2019 Am J Respir Cell Mol Biol Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report Tighe et al. Published Online: Aug 2019 Am J Respir Cell Mol Biol A New Pathway to Airway Relaxation: Targeting the “Other” Cyclase in Asthma Lam et al. Published Online: Jan 2020 Am J Respir Cell Mol Biol Senescence, the Janus of Lung Injury and Repair Wallach-Dayan et al. Published Online: Jul 2019 Am J Respir Cell Mol Biol Give Me Some Room to Breathe! Can Targeting SPHK2 Reduce Airway Smooth Muscle Thickening in Asthma? Ingram Published Online: Jan 2020 Am J Respir Cell Mol Biol See More News & Announcements The Lung Science Podcast The Lung Science Podcast is a collection of engaging interviews and commentaries with luminaries in pulmonary and critical care basic investigation. Listen in as we bring you the best and brightest discussing their work and practical advice for seasoned scientists and trainees alike. Junior Investigator Award The Editors will highlight one or more manuscript for which the first or senior author qualifies as a Junior Investigator in each issue of the published Journal. In addition, the Editor-in-Chief will reward the best manuscript published each year for which the first or senior author is a Junior Investigator by presenting them with an award at the appropriate Assembly at the ATS International Conference in May. At the time of the manuscript's initial submission, the submitting author should indicate if the first or senior author of the manuscript is a Junior Investigator (the definition of a Junior Investigator is a graduate student, fellow, post doc, or Assistant Professor). The submitting author should poll all contributors to determine if the above applies. 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